By testing HLA alleles, amino acids, and SNPs at the same time, also we were able to pinpoint the amino acid position 11 and 13 of HLA‐DRβ1 as a significant signal in both mainland and Hong Kong Chinese Han populations (p = 2.91 × 10−13 both), which was recognized as the major risk factor for SLE in Korean (Kim et al., 2014). This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.