MAPT and early-onset autosomal dominant Alzheimer disease: Tau reduction that can block Aβ‐ and excitotoxin‐induced neuronal dysfunction has been represented to be an effective strategy for treating Alzheimer's disease and related conditions.49 In our previous study, we also demonstrated that UPR could induce increasing tau hyperphosphorylation in different brain regions.9 So we speculated the spatial memory deficit induced by TM was related to hyperphosphorylated tau.