Recent study has found that overexpression of GSK‐3β could cause memory deficits by inhibiting long‐term potentiation which is accompanied by prominent impairment of synapses.34, 35 An in vitro study also show that GSK‐3β could be activated during ER stress 36, 37 and induce tau hyperphosphorylation 23, 38 that be involved in memory impairment. The gene discussed is GSK3B; the disease is memory impairment.