IGF1 and androgen insensitivity syndrome: Taken together, the above results indicate that the upregulated miR-424 levels in circulating immune cells might depress the proliferation of lymphocyte, as well as reduce the levels of pro-inflammatory cytokine (TNF-α), anti-inflammatory cytokine (IL-10), and neurotrophic factor (IGF-1) in plasma, demonstrating the immunosuppressive potential of miR-424 in peripheral immune response for AIS patients.