In a refined mouse model of MS, the MOGTCR×Thy1CFP mouse, which develops optic neuritis only, either spontaneously or following induction with Bordetella pertussis toxin,81 RGC express active caspase-2 and intravitreal injection of a modified siRNA against caspase-2 (siCASP2) protects ~80% of RGC against apoptosis and axonal degeneration,81 suggesting a critical role for caspase-2 in RGC apoptosis after optic neuritis. Here, CASP2 is linked to optic neuritis.