TGFB1 and glaucoma: Acute severe IOP elevation induces I/R injury, but models use less severe IOP elevation to simulate glaucoma, include the photocoagulation laser model,165 injection of hypertonic saline solution,166 injection of paramagnetic microspheres into the anterior chamber, suture-pulley compression,167 intracameral transforming growth factor beta (TGF-β) injection168 and AAV-TGF-β transfection to induce trabecular meshwork fibrosis.169