The decreased glucose disposal rate (GDR) in HFD-fed mice indicated systemic insulin resistance, while insulin-stimulated GDR (IS-GDR) and insulin-induced suppression of plasma FFA levels reflected the relative insulin resistance in muscle and white adipose tissue (WAT) of HFD-fed mice, respectively (Fig. 1o, p, Supplementary Figure S1b). The gene discussed is INS; the disease is Insulin resistance.