In contrast, the cytotoxic activity of free DOX and L-DOX in MV4-11 cells was not affected by ATRA pre-treatment, suggesting that the impact of ATRA pre-treatment on f-L-DOX-mediated cell death was directly due to FRβ overexpression.66 This nanotherapy enables efficient delivery of cytotoxic agents to tumours overexpressing FRβ and could have potential future therapeutic applications in the clinic. This evidence concerns the gene FOLR2 and neoplasm.