Typically, folates are taken up into cells by FRα and FRβ via receptor-mediated endocytosis (RME).11 The folate portion of the conjugate acts as the tumour-targeting ligand and will bind strongly to FRα and/or FRβ receptors on a cancer cell, resulting in subsequent internalisation of the folate–drug conjugate. This evidence concerns the gene FOLR2 and neoplasm.