Avtanski et al. also found that HKL supplementation dramatically upregulated the expression levels of SIRT1 and SIRT3, which promoted the beneficial effect of HKL in antagonizing the oncogenic actions of leptin in breast cancer [19], thus leading us to test HKL and SIRT1 together and to explore their potential relationship in MI/R injury. The gene discussed is SIRT1; the disease is breast carcinoma.