Intriguingly, in our study, HKL showed a strong inhibitory effect against myocardial apoptosis in diabetic heart following MI/R operation, as confirmed by notably reduced apoptotic index, significantly decreased expression levels of cleaved caspase 3 and cytosolic cytochrome c, and remarkably increased ratio of Bcl-2/Bax (Figures 4(a)–4(f)). Here, CASP3 is linked to myocardial infarction.