INS and Insulin resistance: Nevertheless, oxidative stress and H2O2 were described to activate multiple stress-sensitive Ser/Thr kinases such as JNK, ERK1, and IKKb (inhibitor of NF-κB), and p70S6k, which take part in insulin resistance by phosphorylation of IRS1 in serine instead of tyrosine residue, blocking insulin signaling [41].