Stienstra et al. reported that NLRP3/ASC/Caspase-1 deficiency reduced HFD-induced obesity in mice, IR and hepatic steatosis were alleviated in ASC-deficient HFD-fed mice, and the absence of Caspase-1 similarly alleviated IR [55]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.