NRXN3 and alcohol dependence: Moreover, and again using the previous strategy of examining postmortem human tissue expression, in human studies revealing an association with a SNP potentially altering NRXN3 gene splicing (rs8019381, located 23 bp from splicing site 5) and alcohol dependence, individuals with the addiction-associated rs8019381 T allele showed significantly lower levels of transmembrane NRXN3 isoforms [108].