Genes (n = 10) in cluster 2 were entirely labeled as activated stroma (Figure 4A), containing periostin (POSTN), fibronectin 1 (FN1) and collagens (COL10A1, COL11A1), which have already been identified as deregulated in precursor lesions of pancreatic cancer (Erkan et al., 2012). This evidence concerns the gene COL10A1 and pancreatic neoplasm.