ATG16L1 and inflammatory bowel disease: Interestingly, vitamin D receptor (Vdr), autophagy-related 16-like 1 (Atg16l1), and nucleotidebinding oligomerization domaincontaining protein 2 (Nod2), as the best representative IBD-related gene variants, converge to be involved in Paneth cell autophagy (76, 144–147).