DSG3 and acquired polycythemia vera: Interestingly, whereas DRB1*0402−/DQB1*0503+ patients have higher percentage positivity for anti-Dsg1 antibodies when compared with other HLA types, patients who do not express either of the two PV-susceptibility alleles, i.e., DRB1*0402−/DQB1*0503− patients, have a higher likelihood of not bearing anti-Dsg3 or anti-Dsg1 antibodies, suggesting that non-desmoglein autoantibodies may fill this gap (Figure 5C).