Historically, PV has been linked to autoantibodies primarily targeting the desmosomal adhesion molecules desmoglein (Dsg) 3 and, in some cases, Dsg1, two members of the superfamily of cadherin molecules integral to intracellular adhesive junctions (17–19), where they act by steric hindrance and/or induction of intracellular signaling mechanisms (20). Here, DSG1 is linked to acquired polycythemia vera.