Subsequently, high circulating levels of TH17 lymphocytes and IL-17 in patients with acute coronary syndrome, a positive correlation of IL-17 with levels of high-sensitivity C-reactive protein and IL-6 (predicting an increased risk of myocardial infarction) in those patients, and the observation that IL-17 inhibition in mice significantly reduces the size of atherosclerotic plaques, were all interpreted as indicators for a role of TH17 lymphocytes in atherosclerosis (72–74). Here, IL17A is linked to acute coronary syndrome.