The complex role of TANs in tumor angiogenesis and metastasis resides mainly in the capacity of these cells to secrete an array of diverse immunosuppressive or proangiogeneic molecules such as IL-1β, VEGF, FGF2, TGFα, hepatocyte growth factor (HGF), and angiopoietin 1 (ANG1) different chemokines such as CXCL1, CXCL8, CXCL9, CXCL10, CCL3, and CCL4 (6) and enzymes involved in ECM remodeling (MMP9). Here, VEGFA is linked to neoplasm.