Although they are characterized by a terminally differentiated phenotype and a short half-life, these cells are endowed with a certain kind of plasticity and in murine tumor models they are able to differentiate in two distinct subsets: neutrophils type 1 (N1) with antimicrobial functions, and tumor-associated neutrophils (TANs or N2) endowed with protumor and proangiogenic features (Figure 2) in response to TGFβ (81, 82). This evidence concerns the gene TGFB1 and neoplasm.