EPO and anemia: It is thought that increased EPO favors the expression of CD55 and CD59 such as observed in EPO-treated patients with renal anemia (Ohi et al., 2003), which protects from destruction by macrophages, whereas EPO withdrawal decreases expression and coincides with reappearance of anemia (Ohi et al., 2003), resulting in a picture comparable to that observed with EPO-withdrawal and treatment upon descent (Trial and Rice, 2004; Risso et al., 2014).