The result of present study revealed that GLXB treatment significantly protected the myocardium from I/R injury in hyperlipidemia rat, as shown by the decreased level of CK, CK-MB, LDH, cTnI, cTnT, and IL-6, improved cardiac function, and mitigated myocardium damage, consistent with findings in animals with normal blood lipid. Here, TNNI3 is linked to hyperlipidemia.