Therefore, given that SIGMAR1 interacts with the epigenetic machinery, and given that the alkaloids present in Ayahuasca have neurogenic, neuroplastic, neuroprotective and immunomodulatory properties, it seems plausible that these compounds might be useful in diseases such as those of neurodegenerative and transformative nature (i.e., Alzheimer’s disease and cancer) (Jacobs and van Lohuizen, 2002; Fortunato et al., 2009; Tsai et al., 2015; Hwang et al., 2017; Morales-Garcia et al., 2017). This evidence concerns the gene SIGMAR1 and cancer.