(Kourrich et al., 2013; Balasuriya et al., 2014; Beggiato et al., 2017; Feltmann et al., 2018; Ortiz-Renteria et al., 2018) Dysregulation of SIGMAR1 function is implicated in neuropsychiatric and neurodegenerative disorders, drug addiction, cancer, cardiovascular diseases, immune-related pathologies, stroke and neuropathic pain [Reviewed in (Tsai et al., 2009; Frecska et al., 2016)]. The gene discussed is SIGMAR1; the disease is cancer.