In chow-fed WT mice, BIIE0246 increased weight gain, and caused hypercholesterolemia, hyperinsulinemia, and hepatic triglyceride and cholesterol accumulation, which actually resemble the metabolic phenotype of genetically obese NPY mice (Vahatalo et al., 2015; Ailanen et al., 2017). The gene discussed is NPY; the disease is familial hypercholesterolemia.