In spite of much preclinical evidence about the involvement of MMP-2 in acute myocardial infarction (AMI), surprisingly, only one failed clinical trial was conducted by the administration of a non-selective, hydroxamate type MMP inhibitor, PG-116800, in a relatively high dose (400 mg/day) for 90 days for AMI patients (Hudson et al., 2006). This evidence concerns the gene MMP2 and acute myocardial infarction.