In this present study, we induced cellular AD models based on NGF stimulated PC12 cells and primary cerebral cortex neurons by Aβ1–42 insult, and observed that miR-103 increased total neurite outgrowth and inhibited cells apoptosis in both two cellular AD models, and the function of miR-103 in cellular AD models was independent of ADAM10 or NEP. This evidence concerns the gene ADAM10 and Alzheimer disease.