mRNA and protein expressions of potential targeted genes (PTGS2, ADAM10 and NEP) were subsequently determined by qPCR and Western Blot, which illuminated that PTGS2 mRNA was down regulated in miR-103 mimic group than NC1-mimic group and up regulated in miR-103 inhibitor group than NC2-inhibitor group (Figure 5A), but no difference of ADAM10 (Figure 5B) or NEP (Figure 5C) mRNA was observed in PC12 cellular AD model. This evidence concerns the gene ADAM10 and Alzheimer disease.