And we observed that C-Caspase 3 protein expression was decreased in miR-103 mimic group compared with NC1-mimic group while increased in miR-103 inhibitor group compared to NC2-inhibitor group; P-P38 protein expression was elevated in miR-103 mimic group compared with NC1-mimic group and reduced in miR-103 inhibitor group compared to NC2-inhibitor group in both PC12 cellular AD model (Figure 4E). This evidence concerns the gene CASP3 and Alzheimer disease.