PTGS2 and Alzheimer disease: mRNA and protein expressions of potential targeted genes (PTGS2, ADAM10 and NEP) were subsequently determined by qPCR and Western Blot, which illuminated that PTGS2 mRNA was down regulated in miR-103 mimic group than NC1-mimic group and up regulated in miR-103 inhibitor group than NC2-inhibitor group (Figure 5A), but no difference of ADAM10 (Figure 5B) or NEP (Figure 5C) mRNA was observed in PC12 cellular AD model.