After 24 h of transfection of miR-103 and PTGS2 mimic in PC12 cellular AD model, cells apoptosis was determined by Hoechst/PI assay (Figure 6F), which revealed that percentage of apoptosis was increased in miR-103+&PTGS2+ group compared to miR-103+ group, and in PTGS2+ group compared with NC group (Figure 6G). This evidence concerns the gene PTGS2 and Alzheimer disease.