Twenty years of research have indeed indicated that IL-1β is involved in several brain diseases, including multiple sclerosis (Lin and Edelson, 2017), Alzheimer disease (Griffin et al., 2006), epilepsy (Iori et al., 2016), stroke (Murray et al., 2015), and even neurodevelopmental disorders such as schizophrenia and autism (Soderlund et al., 2009; Girard et al., 2010; Krakowiak et al., 2017). Here, IL1B is linked to multiple sclerosis.