We examined whether CE-MS data might underestimate accurate HT amounts in cancer cells, because of its artificial oxidation and/or its rapid turnover in T. Western blotting (Fig. 6a) showed that ADO was diminished; thus, shCD44 cells might utilize glucose to provide 3-phosphoglycerate (3-PG) and L-serine as a one carbon resource38,39 for boosting HT synthesis and subsequent taurine synthesis through oxidative stress in the cells. Here, ADO is linked to cancer.