PLD2 and breast cancer: In addition, overexpression of PLD2 in low-invasive breast cancer cell line MCF-7 cells promotes tumor growth in severe combined immunodeficiency (SCID) mice, while silencing of PLD2 in highly-invasive breast cancer cell line MDA-MB-231 cells significantly abrogates lung metastases in SCID mice16, suggesting that PLD2 in these cancer cells plays a pivotal role in cancer progression.