It was therefore surprising that STEAP2 knockdown would result in a significant up-regulation MMP3. However, one clinical study on prostate tissues has reported a significantly decreased expression of MMP3 in PCa samples when compared to normal prostate and Benign Prostatic Hyperplasia (BPH) samples and this correlated with Gleason score28. This evidence concerns the gene STEAP2 and posterior cortical atrophy.