MAP2K7 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome: GSEA across a larger panel of CRC and PaCa cell lines treated with the BET/MEK combination revealed significant enrichment of these signatures in all cell lines evaluated (Supplemental Figure S11E; Supplemental Table S7), and in a majority of cell lines this enrichment was specific to or enhanced by the combination (Fig. 3a).