PTGS2 and rheumatoid arthritis: The non-steroidal inflammatory drugs (NSAIDs), which include traditional non-selective NSAIDS (nsNSAIDs) and cyclo-oxygenase-2 selective NSAIDs (COXIBs), are widely prescribed and effective for symptom control in chronic diseases such as osteoarthritis (OA), ankylosing spondylitis and rheumatoid arthritis (RA).