Finally, four well-described PI3K isoforms (α, β, δ and γ) are encoded by PIK3CA, PIK3CB, PIK3CD and PIK3CG. Consequently, PIK3 inhibitors are used in targeted therapeutic approaches for several human hematopoietic neoplasias and are in clinical trials for lymphoma types such as indolent non-Hodgkin’s lymphoma and DLBCL43,44. Here, PIK3CB is linked to lymphoma.