Among them, uL18/RPL5 was the strongest candidate and most commonly mutated in human cancer, located at a significant peak of heterozygous deletion and either deleted or mutated in 11% of glioblastoma, 28% of melanoma, 34% of breast cancer patients and more than 20% of advanced multiple myeloma cases82,103. This evidence concerns the gene RPL5 and AL amyloidosis.