In T-cell acute lymphoblastic leukemia (T-ALL), somatic mutations and deletions of RP encoding genes have been reported in about 20% cases, the most frequent ones on uL16/RPL10 (8% of pediatric T-ALL cases) and eL22/RPL22 (10%), with rare defects in uL18/RPL5 (2%) and uL5/RPL11 (1,4%)79,104,105. This evidence concerns the gene RPL5 and acute lymphoblastic leukemia.