In this study, we show that mice with impaired mitochondrial oxidative function in macrophages due to myeloid-specific loss of function of the CR6-interacting factor 1 (Crif1) gene, an essential mitoribosomal factor required for biogenesis of oxidative phosphorylation (OxPhos) subunits, develop systemic insulin resistance associated with adipose inflammation. The gene discussed is GADD45GIP1; the disease is Insulin resistance.