Additionally, in one of the patients with a STAT3 mutation, we detected a 9p copy number gain containing JAK2 (Fig. 2b, Supplementary Fig. 3) and a point mutation in the protein tyrosine phosphatase (PTP) PTPRK, a commonly deleted tumor suppressor shown to negatively regulate STAT3 in NKTCL19. This evidence concerns the gene STAT3 and neoplasm.