EGFR and breast carcinoma: Finally, we checked whether cIAP1 knockdown affected Snai2 accumulation by inhibiting its transcription, as observed in vivo with SM83 treatment, and found that cIAP1 silencing not only reduces the basal levels of Snai2 mRNA, but also prevents its EGFR-dependent increase, both in breast cancer (Fig. 4e) and normal mammary epithelial cells (Fig. 4f).