This was done by analyzing the inflammatory cytokines (TNF-α, IL-1β, and IL-6), performing hematoxylin & eosin (H&E) staining and safranin O-fast green staining of the articular structures of the knee joint to investigate the effects of ChondroT in collagenase-induced osteoarthritis rat model. This evidence concerns the gene IL6 and osteoarthritis.