Accumulative data have confirmed that inflammation of the ocular surface plays an important role in DED [5] and inflammatory markers such as human leukocyte antigen (HLA)-DR [6], interleukin 6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) [7] have been found in the conjunctival and corneal epithelial cells of patients with dry eye. Here, CCL2 is linked to Keratoconjunctivitis sicca.