ANXA5 and neoplasm: Dual radio- and fluorescently-labelled annexin A5 was utilized with in vivo single-photon emission computed tomography (SPECT) imaging of rodent models to investigate the macrophage infiltration of atherosclerotic plaques [70,71], tumor apoptosis visualization [72], prosthetic joint infection [73] and stroke [74] (although the latter is considered to be somewhat controversial [75]).