PTTG1 and neoplasm: MiR-122 negatively regulates the expression of a tumor promoter, N-myc downstream-regulated gene 3 (NDRG3) [82], or pituitary tumor-transforming gene 1 (PTTG1) binding factor (PBF) whose upregulation, because of the loss of miR-122 expression, leads to the cell growth and invasion of the HCC tumor [83].