Mitogen-activated protein kinases (MAPKs) such as extracellular regulated kinase (ERK), p38, and c-Jun-N-terminal kinase (JNK) in signaling plays an important role in NF-κB activation, and the downregulation of mucosal NF-κB signaling may prevent IBD [8,9,10,11,12]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.