APP and amyloidosis: Amyloid plaques containing pE-Abeta peptides generated by the enzymatic activity of QC on N-terminally truncated Abeta peptides derived from hAPP were specifically detected in the neocortex, hippocampus, and amygdala (Figure 3C) but not in subcortical structures, such as the anterodorsal thalamic nucleus (Figure 3A), Edinger-Westphal nucleus, locus coeruleus (Figure 3B), lateral hypothalamus, and perifornical nucleus (Figure 3C).