INS and Hyperglycemia: 2016).As expected, GIP had no effects on plasma glucose or serum insulin concentrations in normoglycemic animals (Holst and Gromada 2004). Neither did the ganglion blocker hexamethonium nor theophylline, an adenosine receptor antagonist in the used concentration (Carlsson et al. 2002b), affect glucose or insulin. In contrast, during hyperglycemia the highest GIP‐dose potentiated glucose‐induced insulin secretion. Our findings on GIP effects on glucose homeostasis were thus in line with previous studies and confirm the physiological effects of the used doses (Svensson et al. 2000, 2005).