To confirm whether HACE1 executes its function in gastric cancer through E3 ligase activity, we established a HACE1 inactive mutant with the HECT domain deleted, HACE1‐deltaHECT, and then performed CCK‐8 and Transwell assays to examine the cell proliferation and migration abilities of the HACE1 inactive mutant cell lines. Here, HACE1 is linked to gastric cancer.