HACE1 and neoplasm: HECT domain and ankyrin repeat‐containing E3 ubiquitin protein Ligase (HACE1), one member of the HECT domain‐containing E3 ligase family, was first brought into our attention by the study of Wilms’ tumor 2 and was then frequently found lost or down‐regulated in many kinds of tumors 3, 4, 5, 6, 7, suggesting its role as a tumor suppressor.