RORA and obesity due to melanocortin 4 receptor deficiency: Although more work is required to tease out the exact molecular processes, this study demonstrates the pivotal role of RORα in energy homeostasis and makes it an interesting therapeutic target for treatments focusing on artificially increasing energy expenditure as a way of handling obesity, all the more so since it has been shown that RORα inverse agonists are also able to decrease hepatic neoglucogenesis (Kumar et al.