In previous studies, MYC has been shown to associate with DNA methyltransferases, which induce the transcriptional silencing of target genes in neuroblastoma18, 35, 36; this suggests that MYCN might play a similar role in the hypermethylation of DKK3. However, we found that the modulation of MYCN silencing had no effects on DKK3 promoter methylation in B‐ALL cell lines. This evidence concerns the gene MYCN and acute lymphoblastic leukemia.