DKK3 and acute lymphoblastic leukemia: In previous studies, MYC has been shown to associate with DNA methyltransferases, which induce the transcriptional silencing of target genes in neuroblastoma18, 35, 36; this suggests that MYCN might play a similar role in the hypermethylation of DKK3. However, we found that the modulation of MYCN silencing had no effects on DKK3 promoter methylation in B‐ALL cell lines.