DKK3 is reported to be a putative antagonist of the Wnt/β‐catenin signalling pathway,7 and activation of this pathway has been implicated in the pathogenesis of leukaemia.24, 25, 26 To explore the effects of MYCN on the Wnt/β‐catenin signalling pathway, we measured the protein levels of p‐GSK3β, GSK3β and both cytoplasmic and nuclear β‐catenin in Nalm6 and BALL‐1 cells by Western blotting. The gene discussed is DKK3; the disease is leukemia.