TLR4 and Insulin resistance: Other than directly inducing cell death, SFAs, specifically palmitate, also play a pivotal role in the induction of inflammatory response via acting as a Toll‐like‐receptor (TLR) 4 ligand, whereby contributing to the development of whole body insulin resistance.22 Palmitate‐elicited TLR4 signalling pathway activation has been reported in both adipocytes and macrophages and TLR4 deletion blunted palmitate‐induced inflammatory signalling in these cells,22 suggesting that TLR4 signalling pathway plays a pivotal role in palmitate‐elicited inflammatory response.