The overall importance of T cells during acute ZIKV infection is further highlighted by the general presence of T-helper type 1 (Th1)–related (IL-2 and IFN-γ), Th2-related (IL-4), Th17-related (IL-17A), and Th9-related (IL-9) cytokines detected in this study, an observation that has been previously reported [34]. This evidence concerns the gene IL4 and Zika virus infectious disease.