Changes in the number of neutrophils (CD45+CD16+), monocytes (CD14+), B cells (CD19+), T cells (CD3+CD4+, CD3+CD8+), double-negative (CD3+CD4-CD8-) T (DNT) cells, NK cells (CD56+ and CD56hi) NK T cells (CD56+CD3+), and CD14+CD56+ cells during acute ZIKV infection were profiled (Figure 2A). The gene discussed is CD8A; the disease is Zika virus infectious disease.