Uniquely, high levels of GM-CSF, IL-2, IL-4, IL-5, IL-6 IL-9, IL-17A, IL-22, MCP-1, HGF, and TNF-α and low levels of PIGF-1 and PGDF-ββ were identified only in the acute phase, making them useful markers for acute ZIKV infection. This evidence concerns the gene IL4 and Zika virus infectious disease.