In the early 90s, work on the molecular characterization of the translocation t(8;21)(q22;q22) in AML led to identification of the RUNX1 gene (previously called AML1, CBFA2, PEBP2aB) from the 21q22 breakpoint and its fusion with RUNX1T1 (previously called AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2) from 8q22 [2]. Here, RUNX1 is linked to acute myeloid leukemia.