Some of the RUNX1-fusions are common, such as ETV6-RUNX1/t(12;21)(p13;q22) in pre-B-ALL and RUNX1-RUNX1T1/t(8;21)(q22;q22) in AML; they have been extensively studied and their prognostic impact is known [4, 5]. Here, RUNX1 is linked to acute lymphoblastic leukemia.