The triplex miRNA and Mir@AFP panels demonstrated a greater diagnostic performance in distinguishing HCC patients with tumor sizes less than 5 cm from LC (triplex miRNA and Mir@AFP panels, AUC = 0.805 and 0.913, respectively) and from CHB (triplex miRNA and Mir@AFP panels, AUC = 0.912 and 0.967, respectively) (Table 2 and Fig 5). This evidence concerns the gene AFP and hepatocellular carcinoma.