Co- alterations (deletion+ methylation) of RBSP3 and LIMD1 were high in the dysplastic lesions (33%, 40% respectively) and HNSCC (29%, 49%) (Fig 4C), with the same increasing with stages of HNSCC, although similar frequencies were observed in Groups 1–4 (data not shown). The gene discussed is CTDSPL; the disease is head and neck squamous cell carcinoma.