CTLA-4 has been implicated in immune dysregulation of various malignancies including esophageal cancer [10], breast cancer [11], lung cancer [12], melanoma [13], non-melanoma skin cancers [14], cervical cancers [15], B-cell chronic lymphocytic leukemia, and non-Hodgkin’s lymphomas [16]. The gene discussed is CTLA4; the disease is breast carcinoma.