We did not observe any differences between IFNARfl/fl x Foxp3YFP-Cre and WT mouse Tregs in expression of Active caspase-3 on day 5 post Armstrong infection again consistent with our data that cell death is not playing a role in reduced Treg suppression in WT mice, although, we cannot exclude the involvement of other cell death pathways. The gene discussed is CASP3; the disease is infection.