To begin to elucidate the mechanistic basis for the suppressive function of IFNAR-deficient Tregs during both acute and Cl-13 infection, we performed high-throughput RNA sequencing of Foxp3+ Tregs from both controls and IFNARfl/fl x Foxp3YFP-Cre mice on day 5 Armstrong and day 25 Cl-13 infection. This evidence concerns the gene FOXP3 and infection.