However, only low levels of IFN-γ and TNF-α were produced and no differences were observed in cytokine production by CD4+Foxp3-CD44+GP66 Tet+ T cells among IFNARfl/fl and IFNARfl/fl x Foxp3YFP-Cre mice on both day 25 and 46-post infection (S3B Fig). The gene discussed is CD44; the disease is infection.