Murine closed‐chest IL‐6 knockout models of myocardial infarction, similar to the one used in our study, exhibit attenuated I/R damage.35 Both NF‐κB and IL‐6 signalling were, after an initial increase, among the pathways shown to be suppressed 24 hours following I/R in animals pretreated with CpG. Here, IL6 is linked to myocardial infarction.